Why Does the Immune System Decline With Age?
July 15, 2026Core Framework & Diagram Immunosenescence and Inflammaging
July 15, 2026Immunosenescence and Inflammaging
There's a fire burning inside you — and it's been burning for decades without you knowing
By the Editors 1-min read
What do heart disease, type 2 diabetes, Alzheimer's disease, and cancer have in common? On the surface, nothing. At the biological level, they share a common substrate: inflammaging — the chronic, low-grade, persistent inflammatory state that accumulates with aging.
It produces no fever, no obvious pain, no acute symptoms. But day by day it depletes immune resources, erodes blood vessels, degrades neural tissue, and promotes tumor growth.
The concept was first proposed by Italian immunologist Claudio Franceschi in 2000 and has since become one of the central research areas in aging medicine. By the end of this article, you'll understand why 'anti-inflammatory' has become the defining keyword in middle-age health management.
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